【摘要】 目的了解本院住院患者抗菌药物的使用情况和趋势,为本院抗菌药物的合理使用提供参考。方法回顾性收集本院2011~2012年住院患者抗菌药物使用数据,以限定日剂量(DDD)为单位,计算抗菌药的使用强度(AUD)并进行分析。结果本院住院患者抗菌药物2011年和2012年的AUD分别为133.29和325.41;每年克拉霉素、阿米卡星、莫西沙星、左氧氟沙星4类药的销售额占总抗菌药销售额的20%,除去这4类药后,本院抗菌药物的AUD分别为68.49和72.08;抗菌药AUD排名前10的药物,头孢类尤其是3代头孢占大多数,其次是青霉素加酶抑制剂类。结论总体来看,本院抗菌药物AUD高于全国综合医院的平均水平,但与综合医院的呼吸科差别不大。提示除有本院的特殊性外,抗菌药的不合理使用也较普遍,应继续加大干预力度,提高合理用药水平。更多还原

【Abstract】 Objective To investigate the application and trend of antibacterials in the inpatients of the hospital,and provide reference for the clinical rational drug application. Methods A retrospective investigation was conducted to analyze the basic situation of the application. The antibacterial use density( AUD) in the inpatients of the hospital was analyzed statistically from 2011 to 2012. Results The AUD of the inpatients in the hospital in 2011 and 2012 were 133. 29 and 325.41,but at the sometime amikacin clarithromycin moxifloxacin and levofloxacin were largely used as antituberculosis drugs in the hospital. When eliminate those medicines,the AUD were 68. 49 and 72. 08. The most frequently used antibacterials were the third-generation cephalosporins and penicillin enzyme inhibitor. Conclusions On the whole,the AUD of the hospital is higher than the national average level,but there is no difference between the respiration departments in other hospitals. Many reasons could be explained those condition but abuse of antibacterials is the main reason. The management of antibacterials should be strengthened.更多还原