【摘要】 目的研究刘氏烫伤膏对深Ⅱ度烫伤新西兰兔创面治疗作用。方法将新西兰兔麻醉后,采用恒温水浴法复制深Ⅱ度烫伤模型;每只动物采用自身对照法,各有5个烫伤部位,分别给予生理盐水、5%磺胺嘧啶锌软膏、刘氏烫伤膏低、中、高剂量;采用透明硫酸纸法比较各组动物烫伤创面愈合率;比较5个部位创面完全愈合时间;取创缘组织制作病理切片,苏木精-伊红染色,按照组织学标准定量评价,比较各组创面愈合情况。结果在给药后第4,7,10,14,21和28天,与阴性对照组比较,阳性对照组、刘氏烫伤膏各剂量组创面愈合率明显提高(P<0.01);创面完全愈合时间缩短(P<0.05);第7和21天各组病理组织切片评分之间无显著性差别(P>0.05),但第14天各组组织病理切片表皮结构、胶原束和皮肤结构、表皮再生、粒细胞浸润评分有显著性差别(P<0.05),阴性对照组评分低于阳性对照组、刘氏烫伤膏各剂量组。结论刘氏烫伤膏可明显提高深Ⅱ度烫伤新西兰兔创面愈合率,缩短创面愈合时间,加速创面愈合。更多还原

【Abstract】 Objective To study the wound healing effect of Liu burn ointment on New Zealand rabbits with deep Ⅱ degree burn.Methods New Zealand rabbits were first anesthetized,then a water bath method was used to copy the deep Ⅱ degree burn model.The self-control method was used on each animal and every of them had 5 burn sites,which were treated with normal saline,5% Zinc sulfasalazine ointment,Liu burn ointment with low,medium and high doses,respectively.Transparent vellum method was used to compare scald wound healing rate among animals in different groups and fully wound healing time was recorded.On day 7,14,21,quantitative histopathological evaluation was carried out.Results On day 4,7,10,14,21,28,compared with the negative control group,wound healing rate of the Zinc sulfasalazine ointment group,Liu burn ointment with low,medium and high doses group was increased(P < 0.01);fully wound healed time was shortened(P < 0.05);on day 7,21,histopathology score had no significant difference among different groups(P > 0.05),but on day 14,the scores of Zinc sulfasalazine ointment group,Liu burn ointment with low,medium and high doses group were significantly higher than that of normal saline group.Conclusions Liu burn ointment can significantly improve wound healing rate,shorten healing time and accelerate wound healing on deep Ⅱ degree burned wound of New Zealand rabbits.更多还原