Aim To examine subcellular localization of serotonin 5-HT2Areceptor( 5-HT2AR) and glutamate NMDA receptor in dorsal hippocampal CA1area( dCA1) and further explore the effect of systemic activation of 5-HT2 AR on hippocampal neuronal firing rate.Methods The distribution of 5-HT2 AR and NMDA receptor in the dCA1 region was detected with immune electron microscopy after embedding. The effect of activation of 5-HT2 AR on the principal neuron and interneuron firing rates was examined with multichannel recording....