【摘要】 目的探讨卵胞浆内单精子显微注射(ICSI)对逆行射精导致的男性不育症的临床治疗价值。方法选取2007年4月一2012年6月在本中心诊治的10例逆行射精患者为研究对象,治疗当天,患者有射精感后立即排尿,留取尿液立即加入培养液,离心清洗后,直接制盘行ICSI治疗;女方采用常规促性腺激素释放激素激动剂(GnRH-a)长方案超促排卵,经阴道穿刺取卵后采用ICSI方式授精。结果 10例逆行射精症患者共完成19个治疗周期,其中2例患者的4个治疗周期因取精当日未发现运动精子改行睾丸穿刺取精加ICSI治疗。其余8例逆行射精患者,共完成15个治疗周期,包括10个新鲜周期和5个冷冻胚胎解冻移植(FET)周期,总受精率为67.97%,卵裂率94.25%,新鲜周期临床妊娠率为66.67%,FEI周期临床妊娠率为60%,总临床妊娠率为64.28%。结论 ICSI治疗逆行射精导致的男性不育症,疗效确切。对于药物及手术治疗无效的逆行射精不育症患者,ICSI是解决其生育问题的很好选择。更多还原

【Abstract】 Objective To explore the clinical therapeutic value of intracytoplasmic sperm injection(ICSI) on retrograde ejaculation-induced male infertility.Methods A total of 10 male patients with retrograde ejaculation-induced male infertility in this center served as research objects.On treatment day,male patients had to urinate immediately after the presence of ejaculation sensation,urine was collected and added with culture medium,centrifuged and cleaned,and directly establish gel to conduct ICSI.As for females,routine gonadotropin- releasing hormone angonist(GnRH-a) was applied to conduct long-protocol controlled ovarian hyperstimulation,and ISCI was conducted for insemination after egg retrival by trans-vaginal puncture.Results All male patients were successfully complete 19-cycle treatment,in which 2 were treated with testicular puncture to collect sperms and ICSI because no movement sperm was found after 4-cycle treatment,while the rest patients finished 15-cycle treatment,including 10 fresh cycles and 5 frozen embryos thawing transplantation(FET) cycles,with total insemination rate,merogenesis rate,clinical pregnancy rate in fresh cycle,clinical pregnancy rate in FET cycle and total clinical pregnancy rate being67.97%,94.25%,66.67%,60%and 64.28%,respectively.Conclusion ISCI has certain efficacy and is the optimal choice in treating retrograde ejaculation-induced male infertility poor with surgeries.更多还原