【摘要】 目的观察职业性慢性轻度镉中毒患者尿镉及尿β2-微球蛋白(β2-MG)水平的变化规律。方法对8例职业性慢性轻度镉中毒患者2005、2007、2008、2010和2012年度的尿镉与尿β2-MG水平(该指标为进行常用对数转换后的对数值)进行跟踪观察和分析比较。结果 2005年首次诊断时,8例患者尿镉水平为(86.71±24.04)mg/kg肌酐,在脱离镉接触后,尿镉水平呈下降趋势;2012年尿镉水平为(30.97±11.28)mg/kg肌酐,低于2005年水平(P<0.05)。2005年首次诊断时尿β2-MG水平的对数值为(3.62±0.30)mg/kg肌酐,脱离镉接触后仍有缓慢升高趋势;2012年尿β2-MG水平的对数值为(4.02±0.41)mg/kg肌酐,高于2005年水平(P<0.05)。结论慢性镉中毒患者脱离镉接触后,尿镉水平可有一定程度下降,而肾小管功能损害仍无好转迹象。更多还原

【Abstract】 Objective To observe the variations of urinary cadmium and urinary β2-micro-globulin( β2-MG) in occupational chronic mild cadmium poisoning. Methods The levels of urinary cadmium and urinary β2-MG( it was transformed to a common logarithm) of 8 cases of occupational chronic mild cadmium poisoning were tracing observed,analyzed and compared in 2005,2007,2008,2010 and 2012. Results The level of urinary cadmium was(86. 71 ± 24. 04) mg / kg Cr in 2005. After 2 years’ removal from cadmium exposure,it decreased obviously. In 2012,it was(30. 97 ± 11. 28) mg / kg Cr and lower significantly than that in 2005( P < 0. 05). The logarithm value of urinary β2-MG level was(3. 62 ± 0. 30) mg / kg Cr in 2005,but it trended to increase after removal from cadmium exposure. And in 2012,it was(4. 02 ± 0. 41) mg / kg Cr and higher significantly than that in 2005( P < 0. 05). Conclusion The level of urinary cadmium in chronic cadmium poisoning cases might decrease after removal from cadmium exposure,but without a sign of improvement in renal tubular dysfunction.更多还原