【摘要】 目的观察不同检测时段的瞬时弹性成像(FS)下肝硬度值变化。方法收集4 731例次慢性肝病FS肝纤维化检测结果,比较每日9个不同时段肝硬度值的差异。以肝硬度值为因变量,以检测时段、性别、是否住院患者等3个因素为主效应因素,年龄为协变量进行协方差分析。结果4 731例次平均肝硬度值为(8.8±8.3)kPa。不同时段肝硬度值比较总体差异有统计学意义(P<0.05),每日10、11、9、8、7时段肝硬度值接近,低于17、16、14、15时段肝硬度值(P均<0.05)。不同时段中性别、年龄分布、住院患者比例比较差异均有统计学意义(P<0.01或0.006)。检测时段、性别、是否住院患者、年龄对肝硬度值均存在单独的影响(P<0.01);在不同的检测时段和性别和(或)是否住院的组合对肝硬度值还存在附加影响(P<0.01)。结论检测的时段可能影响肝硬度值,FS检测应固定于上午一个时段内进行。更多还原

【Abstract】 Objective To observe the changes in the liver stiffness( LS) measured by fibroscan( FS) at different time points. Methods Transient elastography results of 4731 cases with chronic hepatopathy were retrospectively analyzed and the discrepancy among the values measured at nine time points was statistically compared. LS was regarded as the dependent variable,detection time point,gender,and hospitalization or not as main effect factors and age as the covariate. Univariate analysis of covariance was performed. Results Mean LS level of all 4731 subjects was( 8. 8 ± 8. 3) kPa. The LS measured at different time points significantly differed( P < 0. 05). LS levels detected at 10,11,9,8 and 7 a. m. were almost similar,whereas significantly lower than those measured at 17,16,14 and 15 p. m.( all P < 0. 05). Gender,age and the proportion of hospitalized patients significantly differed among different time points( P < 0. 01 or 0. 006). Detection time point,gender,hospitalization or not,and age are independent factors affecting LS levels( all P < 0. 01).These three factors equally exert a combined effect upon LS levels( P < 0. 01). Conclusion Detection time point probably affects the measurement of LS. Therefore,the measurement of LS should be conducted at a fixed period in the morning.更多还原