【摘要】 目的:观察中医益气生血法对中晚期鼻咽癌放化疗疗效及不良反应的影响。方法:68例初治中晚期鼻咽癌患者随机分为2组,观察组(中药联合放化疗组)35例,对照组(放化疗组)33例。两组均采用常规放疗同期行PF方案化疗。观察组从放疗开始联合使用益气生血类中药直至放疗结束。比较两组病人在治疗期间肿瘤消退情况、血红蛋白改善情况、放疗急性反应等。结果:观察组的肿瘤缓解率(PR+CR)高于对照组分别为91.4%(32/35)和84.8%(28/33),但无统计学上的显著差异(P=0.471);观察组血红蛋白显著升高(P<0.001);观察组乏力发生率明显少于对照组(P<0.001)。结论:益气生血法对同步放化疗短期疗效无明显影响,但可减轻放化疗毒副反应,提高生活质量。更多还原

【Abstract】 Objective: To investigate the efficacy and safety of Yiqi Shengxue Soup combined with concurrent chemoradiation in locally advanced nasopharyngeal cancer patients. Methods: Eligible patients with no prior chemoradiation were randomly assigned to receive concurrent chemoradiation( regular radiation with DDP plus 5- FU) with or without Yiqi Shengxue Soup. The primary endpoint was objective response rate and secondary endpoint was the incidence of adverse events. Results: 68 patients,35 in concurrent chemoradiation with Yiqi Shengxue Soup group( combination group) and 33 in concurrent chemoradiation alone group( control group) were recruited. The objective response rate( PR + CR) was numerically but not statistically higher in combination group than in control group( 91. 4% VS 84. 8%,P =0. 471). The absolute value of hemoglobin at the end of treatment was significantly higher in combination group( 110. 06 ± 6. 17 vs 90. 70 ± 5. 48,P < 0. 001). The incidence of grade3 /4 fatigue was significantly lower in combination group( 2. 9% vs 30. 3%,P <0. 001). Conclusion: Yiqi Shengxue Soup reduced the incidence of anemia and acute radiation effect of concurrent chemoradiation and improved the quality of life in locally advanced nasopharyngeal cancer patients.更多还原