Objective To observe the efficacy of hydrochlorothiazide combined with enalapril or irbesartan in the treatment of moderate and severe primary hypertension. Methods Sixty-one patients with moderate and severe hypertension,who were enrolled in the hospital from February 2012 to August 2013,were selected and randomized into the group of hydrochlorothiazide combined with enalapril(HE group,n=28)and the group of hydrochlorothiazide combined with irbesartan(HI group,n=33),and the clinical efficacy was analyzed b...