【摘要】 目的观察多西他赛(TAX)和洛铂(LBP)组成的TL化疗方案治疗老年晚期非小细胞肺癌(NSCLC)的疗效和毒性反应。方法选择2011年1月至2012年12月南昌市第三医院采用TL(TAX联合LBP)化疗方案治疗的26例老年晚期NSCLC患者,将TAX 75 mg/m2溶于生理盐水250 mL或5%葡萄糖溶液250 mL中,静脉滴注1 h;另将LBP 30 mg/m2溶于5%葡萄糖溶液250 mL中,静脉滴注3 h;3周为1个周期。结果所有患者中无一例完全缓解,获部分缓解4例(15.4%),稳定13例(50.0%),进展9例(34.6%),有效率为15.4%,肿瘤控制率为65.4%;主要毒性反应为骨髓抑制,尤以血小板减少为重,未发现明显的肾功能损伤。结论 TAX联合LBP治疗老年晚期NSCLC的疗效较好,但临床上采用该方案治疗的同时应加强血细胞监测及造血因子支持。更多还原

【Abstract】 Objective To study the toxicity and efficacy of chemotherapy with docetaxel(TAX) combined with lobaplatin(LBP) for elderly patients with advanced non-small cell lung cancer(NSCLC). Methods From January 2011 to December2012,26 elderly patients with advanced NSCLC were treated with TL(TAX combined with LBP) for chemotherapy regimens. TAX75 mg/m2 was dissolved in 250 mL normal saline(NS) or 250 mL 5% glucose solution for 1-h intravenous drip;LBP 30 mg/m2 was dissolved in 250 mL 5% glucose solution for 3-h intravenous drip. 3 weeks was taken as a period. Results Among the 26 patients,4 cases got partial remission(15.4%),13 cases got stable(50.0%) and 9 cases got progressive(34.6%) with the effective rate of 15.4% and disease control rate of 65.4%. The main toxicities were myelosuppression,especially thrombocytopenia. Serious renal toxicity did not appeared. Conclusion This combination therapy of TAX and LBP has good effect for elderly patients with advanced NSCLC,but hematopoietic factor support should be strengthened when the therapy is adopted in clinic.更多还原