【摘要】 目的探讨类风湿关节炎(RA)与颈动脉粥样硬化症(CAS)的相关性。方法将该院2010年6月至2013年6月诊治的RA患者130例(RA组),根据改良的疾病活动性评分分为4个亚组(RA1、RA2、RA3、RA4),选择同期健康体检者96例作为对照组。分析各组颈动脉内膜增厚情况及颈动脉斑块数量,并探讨CAS相关性因素。结果 RA组患者CAS发生率高于对照组,差异有统计学意义(P<0.05),但缓解期患者CAS检出率与对照组比较,差异无统计学意义(P>0.05),活动期患者发生CAS检出率明显高于对照组,差异有统计学意义(P<0.01)。进行Logistic回归分析,发现类风湿因子滴度、年龄、红细胞沉降率、C-反应蛋白是CAS的危险因素。结论 RA与CAS的发生和发展关系密切。更多还原

【Abstract】 Objective To study the relevancy of rheumatoid arthritis(RA) and carotid atherosclerosis(CAS). Methods A total of 130 patients with RA(RA group),who were received in the hospital from June 2010 to June 2013,were divided into 4subgroups(RA1,RA2,RA3 and RA4) according the modified disease activity score-28(DAS28),simultaneously,other 96 health subjects were selected as control group. The amounts of carotid artery intima media thickness and carotid arteriosclerosis plaques in all the groups were analyzed,and the interrelated factors of CAS were disucssed. Results The occurrence rate of patients with CAS in RA group was significantly higher than that of the people in the control group(P<0.05),but there was no statistically signif icant difference between the RA patients in remission stage and the people in control group on the occurrence of CAS(P>0.05),and the detection rate of CAS of the RA patients in active stage was obviously higher than that of the people in the control group(P<0.01). The Logistic analysis of the regression showed that the rheumatoid factors titer,age,erythrocyte sedimentation rate,C reactive protein were risk factors for CAS. Conclusion RA is closely related to the occurrence and development of CAS.更多还原