YSY-01 A has shown proliferation inhibitory activity to certain types of tumor cells by inhibiting proteasome. However, its effect on autophagy, which is related with the ubiquitin proteasome pathway(UPP), remains unclear. Our study aimed to find out its effect on autophagy and possible molecular mechanisms. The results suggested that YSY-01 A significantly(P<0.001) inhibited proliferation of PC-3M cells(IC50 was 287 nM for 48 h) in a concentration-dependent and time-dependent manner. YSY-01A(100 nM, 3 h) a...
【基金】
Eleventh Five-Year Plan for National Science and Technology Major Project(Grant No.2009ZX0930-010);
National Science Foundation of China(Grant No.81172915);
a grant from Major New Drugs Research and Development Platform of Peking University(Grant No.2009ZX09301-010)
【更新日期】
2014-10-15
【分类号】
R962
【正文快照】
1.IntroductionAutophagy is anevolutionarily conserved catabolicprocess,which occurs when cells are in the state ofstarvation or stress.It was first discovered in yeast.Organells and proteins are packed in autophagosomes,delivered to lysosome for recycling
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