Chronic alcohol consumption induces hepatic steatosis, the early stage of alcoholic liver disease(ALD). The aim of present study is to investigate the protective effect of Panax notoginseng saponins(PNS) against chronic ethanol-induced hepatic steatosis in vivo. Mice were pair-fed a modified Lieber-DeCarli liquid diet containing alcohol or isocaloric maltose dextrin as control diet with or without PNS(200 mg/kg, BW) for 8 weeks. Animals supplemented with PNS were protected against hepatic lipid accumulation...
【基金】
Research Committee of the University of Macau(Grant No.MYRG123-ICMS12 and MYRG111-ICMS13);
from Macao Science and Technology Development Fund(Grant No.010/2013/A1)
【更新日期】
2014-08-08
【分类号】
R285.5
【正文快照】
1.IntroductionLong-term excess alcohol consumption leads tofatty liver(hepatic steatosis),characterized by lipiddroplet accumulation(mainly triglycerides,or TG)inhepatocytes[1].Fatty liver was initially assumed tobe a benign and reversible condition[2].An
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