【摘要】 目的对不同剂量理中汤超微配方颗粒与传统饮片治疗胃脘痛的临床疗效进行比较研究。方法将60例符合中医脾胃虚寒证诊断标准的胃脘痛患者随机分为传统汤剂组、1/3剂量组和1/5剂量组,分别予传统理中汤饮片制剂、1/3剂量的超微配方颗粒和1/5剂量的超微配方颗粒。比较分析3组用药1个疗程后的临床疗效。结果 3组在年龄、病程、治疗前证候积分、胃脘痛疾病疗效和证候疗效方面,组间比较差异无统计学意义(P>0.05),3组均能降低胃脘痛的严重程度、频率和持续时间,治疗前后比较差异有统计学意义(P<0.05)。结论传统理中汤饮片制剂、1/3剂量超微配方颗粒和1/5剂量超微配方颗粒治疗胃脘痛的疗效无明显差异,且1/3剂量组与传统汤剂组的疗效十分接近。更多还原

【Abstract】 Objective To compare the clinical efficacy of different doses of ultrafine extracted granule preparation(EGP) and traditional herbal decoction(THD) of Li Zhong Tang in treatment of epigastric pain. Methods Sixty cases of epigastric pain patients in accordance with the diagnostic criteria of deficiency and cold pattern of spleen and stomach in TCM were randomly divided into THD group, 1/3 dose group and 1/5 dose group, and were given THD, 1/3 dose of ultrafine EGP and 1/5 dose of ultrafine EGP, respectively. The clinical efficacy of the three groups after one course of medication was comparatively analyzed. Results There were no significant differences in age, course of disease, symptom score before treatment, epigastric pain efficacy and syndrome curative effect among the three groups, the differences had no statistical significance(P >0.05). The severity, frequency and duration of epigastric pain were all reduced in the three groups, with significant differences between before and after treatment(P <0.05). Conclusion There are no significant differences in the clinical efficacy on epigastric pain among THD, 1/3 dose of ultrafine EGP and 1/5 dose of ultrafine EGP. In addition, the effect of 1/3 dose group is very close to the THD group.更多还原