【摘要】 目的 探讨冠心病患者大内皮素-1(big ET-1)与颈股动脉脉搏波传导速度(cf-PWV)的关系。方法 纳入95例冠心病患者,检测其大内皮素-1、颈股动脉脉搏波传导速度、血压、超敏C反应蛋白(hs-CRP)等指标。应用多因素回归方法 分析大内皮素-1与颈股动脉脉搏波传导速度的关系。结果 在单因素分析中,血浆大内皮素-1水平与年龄、血压(收缩压、舒张压、平均动脉压和脉压差)、超敏C反应蛋白、腰围、空腹血糖、血尿素氮和低密度脂蛋白水平呈正相关。在单因素分析中,大内皮素-1与颈股动脉脉搏波传导速度没有显著的统计学关系(r=0.014,P>0.05);在多因素分析中,血浆大内皮素-1水平与颈股动脉脉搏波传导速度也没有显著的统计学关系(P>0.05)。结论 本研究没有发现冠心病患者大内皮素-1与动脉僵硬度之间有着独立的显著性相关性,提示内皮素系统可能不是冠心病患者动脉僵硬度升高的重要因素。更多还原

【Abstract】 Objective To evaluate the association between big ET-1 and cf-PWV in CAD patients.Methods We enrolled 95 CAD patients and obtained plasma big ET-1,cf-PWV,blood pressure,CRP(C-reactive protein),and cf-PWV.Multiple regression analyses were used to assess the relationships between big ET-1and both PWVs.Results In this study,plasma big ET-1 positively correlated with age,blood pressure(SBP:systolic blood pressures,DBP:diastolic blood pressures,MAP:mean arterial blood pressure,PP:pulse pressure),log hs-CRP,log big ET-1,waist circumference,fasting glucose,BUN(blood urea nitrogen) and LDL-C(low-density lipoprotein cholesterol).In multivariate analysis,the plasma big ET-1 levels were not significantly associated with cf-PWV in CAD patients(P>0.05).Conclusion In this study,we did not find a significant and independent relationship between plasma big ET-1 level and arterial stiffness measured by cf-PWV in CAD patients.More research may be needed.更多还原