【摘要】 目的 通过左西孟旦对顽固性心衰患者脑钠肽前体(pro-BNP)、心脏彩超左室射血分数(LVEF)及左室舒张末容积(LVEDV)、室性心律失常的影响,观察研究左西孟旦治疗顽固性心衰患者的效果。方法 筛选出顽固性心衰患者80例,随机分成2组,分别给予左西孟旦和米力农治疗,治疗前后分别测pro-BNP、LVEF、LVEDV和室性心律失常的次数。结果 与对照组相比,经左西孟旦治疗后患者的pro-BNP和室性心律失常的次数显著下降;两组间LVEDV下降值差异无统计学意义;左西孟旦组LVEF显著升高。结论 左西孟旦治疗顽固性心衰优于传统正性肌力药物。更多还原

【Abstract】 Objective This study addressed to measure pro-brain natriuretic peptide(pro-BNP),left ventricular ejection fraction(LVEF),left ventricular end diastolic volume(LVEDV) and ventricular arrhythmia in patients with refractory heart failure,aims to observe the efficacy of Levosimendan.Methods Eighty patients with refractory heart failure were divided into two groups randomly and received Levosimendan or Milrinone treatment respectively.The dates of pro-BNP,LVEF,LVEDV and times of ventricular arrhythmia at pretherapy and posttreatment were recorded.Results Compared with control group,the levels of pro-BNP and times of ventricular arrhythmia in Levosimendan group were significantly lower.The decrease of LVEDV in the two groups were no different.The value of LVEF was higher than Levosimendan group.Conclusion Levosimendan is better in treating refractory heart failure than traditional positive inotropic drug.更多还原