【摘要】 目的:分析曲美他嗪对经皮冠状动脉介入治疗术(PCI)心肌损伤及术后再发心绞痛症状的影响。方法:以随机数字表法抽选96例不稳定型心绞痛患者,均在基础治疗上行PCI,分为曲美他嗪组(48例)和常规治疗组(48例);比较两组心绞痛再发情况,以及对手术心肌损伤作用的差异。结果:PCI手术后各时间点两组患者的cTnI水平不断升高,除手术后1h外,其余时间段两组的cTnI水平均有明显差异(P<0.05或<0.01),且术后24h两组间cTnI水平差异最明显[曲美他嗪组的cTnI(0.21±0.12)ng/ml显著低于常规治疗组的(0.66±0.12)ng/ml],P<0.01;随访期间,与常规治疗组比较,曲美他嗪组心绞痛再发生率明显降低(29.17%比8.33%),左室射血分数明显提高[(50.89±2.45)%比(57.11±2.13)%],P均<0.05。结论:曲美他嗪对经皮冠状动脉介入治疗术后心肌有一定保护作用,并且对再发心绞痛症状有一定减少作用。更多还原

【Abstract】 Objective:To analyze the influence of trimetazidine on percutaneous coronary intervention(PCI)-induced myocardial injury and postoperative recurrence of angina pectoris.Methods:A total of 96 patients with unstable angina pectoris(UAP)were selected according to random number table,all patients received PCI based on basic therapy and they were divided into trimetazidine group(n=48)and routine treatment group(n=48);recurrence of angina pectoris and condition of myocardial injury after PCI were compared between two groups.Results:Beside 1h after PCI,the cTnI levels continuously elevated in each time point after PCI in both groups(P<0.05or<0.01),and cTnI level difference was most significant between two groups on 24 hafter PCI[cTnI(0.21±0.12)ng/ml in trimetazidine group was significantly lower than that of routine treatment group[(0.66±0.12)ng/ml,P<0.01];During follow-up,compared with routine treatment group,there was significant reduction in recurrence rate of angina pectoris(29.17% vs.8.33%)and significant rise in left ventricular ejection fraction[(50.89±2.45)% vs.(57.11±2.13)%]in trimetazidine group,P<0.05 both.Conclusion:Trimetazidine possesses certain protective effect on myocardium after percutaneous coronary intervention and has certain reduction in recurrent angina pectoris.更多还原