【摘要】 目的:探讨急性冠脉综合征(ACS)患者血清白细胞介素(IL)-7表达水平并分析其与预后的关系。方法:选择ACS患者130例(急性心肌梗死70例,不稳定型心绞痛60例)、稳定型心绞痛患者33例(SAP组)、健康体检者89例(健康对照组),使用ELISA法检测各组IL-7水平并进行比较,并跟踪随访130例ACS患者的病情,通过Log istic回归分析判断IL-7水平与预后的关系。结果:与健康对照组和SAP组比较,UAP组和AMI组IL-7水平均显著升高[(1.84±0.47)pg/ml、(2.11±0.63)pg/ml比(4.87±0.52)pg/ml、(5.15±0.71)pg/ml,P<0.05或P<0.01],健康对照组与SAP组,UAP组与AMI组之间IL-7水平无显著差异(P均>0.05);Log istic回归分析显示,ACS患者血清中IL-7的水平是发生不良心血管事件的独立危险因素(OR=1.212,95%CI:1.061~1.418)。结论:白细胞介素-7作为机体重要的炎症因子之一,其水平在急性冠脉综合征患者的异常升高,可能具有判断疾病预后的重要价值。更多还原

【Abstract】 Objective:To explore the expression level of serum interleukin(IL)-7 in patients with acute coronary sy ndrome(ACS)and analy ze the relationshipbetween IL-7 level and prognosis.Methods:A total of 130 ACS patients[AMI group,ineluding70 cases with acute my ocardial infarction(AMI)and 60 cases with unstable angina pe ctoris(UAP)],33 cases with stable angina pectoris(SAP,SAP group)and 89 healthy subj ects(healthy control group)were selected.IL-7level was measured usingenzy me linked immunosorbent assay(ELISA)and compared amongall groups.The 130 ACS patients were followed up,and Logistic regression analy sis was used to analy ze the relationshipbetween IL-7 level and prognosis.Results:Compared with healthy control groupand SAP group,there was significant rise in IL-7 level in UAP groupand AMI group[(1.84±0.47)pg/ml,(2.11±0.63)pg/ml vs.(4.87±0.52)pg/ml,(5.15±0.71)pg/ml,P<0.05 or P<0.01].There were no significant difference in IL-7level between healthy control groupand SAP group,UAP groupand AMI group(P>0.05 both);Logistic regression analy sis indicated that expression level of serum IL-7 was an independent risk factor for adverse cardiovascular events in ACS patients(OR=1.212,95%CI:1.061-1.418).Conclusion:Interleukin-7,as an important inflammatorycy tokines,its serum level abnormally elevated in patients with acute coronary sy ndrome,it may have important prognostic value.更多还原