【摘要】 目的:探讨阿托伐他汀对动脉粥样硬化早期血管保护的作用。方法:选择具有2个以上心血管危险因素而没有动脉粥样硬化斑块的患者120例,随机均分为4组,均予以控制心血管危险因素治疗。其中对照组不使用阿托伐他汀干预,5mg组、10mg组、20mg组予以不同剂量的阿托伐他汀干预。随访6月,观察血栓素B2(TXB2)、6-酮-前列腺素F1α(6-Keto-PGF1α)、臂踝脉搏波传导速度(baPWV)、踝臂指数(ABI)以及颈动脉内膜中层厚度(IMT)的变化。结果:4组治疗前后ABI和IMT无显著变化(P均>0.05)。与基线比较,治疗后对照组和5mg组TXB2、baPWV水平显著升高,6-Keto-PGF1α水平显著降低;与之相反,10mg组、20mg组TXB2、baPWV水平显著降低,6-Keto-PGF1α水平显著升高(P<0.05~<0.01)。治疗6个月后与对照组和5mg组比较,10mg组、20mg组的TXB2[(148.3±29.2)pg/ml,,(142.3±30.6)pg/ml比(111.5±22.8)pg/ml,(104.9±17.4)pg/ml]、baPWV[(1621.1±136.1)cm/s,(1597.7±125.3)cm/s比(1232.9±132.3)cm/s,(1178.2±155.1)cm/s]水平显著降低,6-Keto-PGF1α[(104.7±66.1)pg/ml,(102.2±70.3)pg/ml比(132.8±48.3)pg/ml,(139.1±66.3)pg/ml]水平显著升高(P<0.05~<0.01)。结论:阿托伐他汀对动脉粥样硬化早期血管有保护的作用,10mg阿托伐他汀可能是血管保护的最低有效剂量。更多还原

【Abstract】 Objective:To explore protective effect of atorvastatin on blood vessels in early stage of atherosclerosis(AS).Methods:A total of 120 patients without AS plaques,who had>2cardiovascular risk factors and received control cardiovascular risk factors therapy,were randomly divided into four groups:control group(did not receive atorvastatin),atorvastatin 5mg group,10 mg group and 20 mg group(received corresponding dose of atorvastatin).All patients were followed up for six months,changes of thromboxane B2(TXB2),6-Keto-prostaglandin F1α(6-Keto-PGF1α),brachial-ankle pulse wave velocity(baPWV),ankle brachial index(ABI)and intima-media thickness(IMT)were observed.Results:There were no significant changes in ABI and IMT between before and after treatment among four groups(P>0.05all).Compared with baseline,TXB2、baPWV levels significantly rose,6-KetoPGF1αlevel significantly decreased after treatment in control group and 5mg group;in contrast,TXB2、baPWV levels significantly decreased,6-Keto-PGF1αlevel significantly rose after treatment in 10 mg group and 20 mg group(P<0.05~<0.01).After treatment six-month,compared with control group and 5mg group,the TXB2[(148.3±29.2)pg/ml,(142.3±30.6)pg/ml vs.(111.5±22.8)pg/ml,(104.9±17.4)pg/ml]、baPWV[(1621.1±136.1)cm/s,(1597.7±125.3)cm/s vs.(1232.9±132.3)cm/s,(1178.2±155.1)cm/s]levels significantly decreased,6-Keto-PGF1α[(104.7±66.1)pg/ml,(102.2±70.3)pg/ml vs.(132.8±48.3)pg/ml,(139.1±66.3)pg/ml]level significantly rose(P<0.05~<0.01)in 10 mg group and 20 mg group.Conclusion:Atorvastatin has protective effect on blood vessels in early stage of atherosclerosis,and 10 mg atorvastatin may be the minimum effective dosage to protect blood vessels.更多还原