【摘要】 目的了解浙江省部分汉族人群乙醛脱氢酶2(ALDH2)基因多态性分布频率。方法在浙江省地区收集1370例汉族人血液标本,对其ALDH2基因12号外显子的特定片段进行特异性扩增,应用基因芯片法判定基因型。结果 ALDH2变异型等位基因在浙江省部分汉族人群中的分布频率为44.5%;此人群的ALDH2基因型频率分布与上海人群之间的差异不存在统计学意义,而与洛阳人群之间存在统计学意义。结论浙江省部分汉族人群ALDH2基因变异型有将近一半,表明此人群中ALDH2酶活性缺乏者占近半数;中国汉族人群的ALDH2基因多态性似存在南北地区差异。更多还原

【Abstract】 Objective To investigate the ALDH2 gene polymorphism in part of Han population in Zhejiang province. Methods With 1370 blood samples of Han population in Zhejiang province, the specific fragment of ALDH2 gene exon 12 were amplified using gene chip technique to judge the genotypes. Results The frequency distribution of ALDH2 mutant alleleswas 44.5% in Han population of Zhejiang province. There was no statistical differences between the distributions of ALDH2 genotype frequencies of the population in Zhejiang province compared with that in Shanghai district;while there was a difference when compared to the population of Luoyang population. Conclusions The percentage of ALDH2 gene variant in Han population of Zhejiang province was nearly half, which showed that the percentage of people lacking ALDH2 enzyme activity was nearly half; and there was a regional difference of ALDH2 gene polymorphism between north and south in Chinese Han population.更多还原