【摘要】 目的探讨脑室外引流发生脑室炎的相关危险因素。方法回顾性分析2007年1月~2012年12月于泸州市人民医院接受脑室外引流的300例患者的临床资料,根据脑室感染情况分为脑室炎组和对照组。对可能的危险因素进行单因素和多因素Logistic回归分析。结果单因素分析发现,脑室炎症的发生与手术时间(>4 h)、引流天数(≥7 d)、手术次数(≥2次)、切口脑脊液漏、尿激酶脑室灌注、原发疾病等因素有相关性(P<0.05或P<0.01),与性别、年龄等因素无相关性;多因素Logistic回归发现,手术时间、引流天数、手术次数、切口脑脊液漏、尿激酶脑室灌注、原发疾病皆是脑室外引流患者脑室炎症的独立危险因素。结论脑室外引流发生脑室炎是多因素共同作用的结果,手术时间、引流天数、手术次数、切口脑脊液漏、尿激酶脑室灌注、原发疾病是术后脑室炎的独立危险因素。及早针对危险因素采取有效的预防措施,有助于降低脑室炎症的发生。更多还原

【Abstract】 Objective To explore the risk factors in the occurrence of postoperative ventriculitis in patients with external ventricular drainage. Methods A retrospective analysis was made to the clinical data of 300 patients of external ventricular drainage made in the People’s Hospital of Luzhou City during the time from January 2007 to December 2012; based on the degree of ventricular infection,the patients were divided into 2 groups: ventriculitis group and control group. Univariate and multiple logistic regression analysis was used to determine the possible risk factors associated with ventriculitis. Results Univariate logistic regression analysis showed that the occurrence of ventriculitis was mainly correlated to operation time length( > 4 h),days of external ventricular drainage( ≥7 days),times of operations( ≥2),cerebrospinal fluid leakage,intraventricular perfusion of urokinase,primary diseases( P <0.05or P < 0. 01),while it was not correlated to sex and age; multiple logistic regression analysis found that operation time length,days of external ventricular drainage,operations times,cerebrospinal fluid leakage,intraventricular perfusion of urokinase,primary diseases were the independent risk factors for ventriculitis in patients of external ventricular drainage. Conclusions Ventriculitis after external ventricular drainage occurs due to the interaction of multiple factors,and operation time length,days of external ventricular drainage,operations times,cerebrospinal fluid leakage,intraventricular perfusion of urokinase,primary diseases are the independent risk factors;early preventive measures against ventriculitis can reduce the occurrence.更多还原