The administration of lipopolysaccharide(LPS), a component of the cell wall of gram negative bacteria, is commonly-used method to cause immune activation and the release of cytokines both in the periphery and in the brain in rodents. The cytokine theory of depression indicated that pro-inflammatory cytokines play an important role in the pathological mechanism of depression. Many studies used the peripheral administration of LPS to induce depressive-like behaviors. However, in these studies, the altered beh...
1引言抑郁症中伴有免疫功能异常的观点提出已经有20年,但这些异常在抑郁症的发病机理中如何发挥作用,仍然没有得到清晰阐释(Maes et al.,2009;Miller,Maletic,&Raison,2009)。在众多研究中,比较一致的发现是抑郁症患者血浆中炎性细胞因子的水平升高,包括IL-1β、IL-6、TNF-α以
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