【摘要】 目的通过分析人群血清胰岛素受体(InsR)α、β表达水平,探讨其与冠心病(CHD)的相关性及临床意义。方法通过抽签法随机抽取2011年1月至2012年10月门诊及住院人群中CHD患者120例及非CHD对照组118例,并根据是否合并2型糖尿病(T2DM)分为:(1)CHD合并T2DM组61例;(2)CHD非T2DM组59例;(3)非CHD单纯T2DM组60例;(4)非CHD非T2DM组58例。采用酶联免疫分析法测定以上4组人群血清InsR-α、β表达水平,并比较组间差异。结果CHD患者中,合并T2DM组血清InsR-α、β水平均较非T2DM组降低[(0.21±0.02)U/L比(0.35±0.06)U/L,(0.25±0.01)U/L比(0.39±0.02)U/L,均为P<0.05];对照组中,单纯T2DM组血清InsR-α、β水平均较非T2DM组降低[(0.32±0.03)U/L比(0.43±0.01)U/L;(0.40±0.04)U/L比(0.49±0.05)U/L,均为P<0.05]。而CHD合并T2DM组血清InsR-α、β水平较单纯T2DM组降低,CHD非T2DM组患者血清InsR-α、β水平较非CHD非T2DM组降低(均为P<0.05)。结论 InsR表达水平改变可能协同参与了高胰岛素血症及胰岛素抵抗的形成过程,而与CHD的发生发展相关。更多还原

【Abstract】 Objective To investigate the relationship between the level of insulin receptor α,β and coronary heart disease(CHD).Methods From January 2011 to October 2012,120 patients with CHD(group 1: with T2DM; group 2: without T2DM) and 118 patients without CHD(group 3: with T2DM;group 4: without T2DM) were randomly enrolled in this study by the method of lottery.The serum insulin receptor α,β were detected in all the subjects by ELISA.Variance analysis was used for data analysis among the 4 groups.Results The serum levels of Insulin receptor-α,β in patients with T2DM were all significantly lower than those without T2DM [α:(0.21 ± 0.02) U/L vs.(0.35 ± 0.06) U/L,(0.32 ±0.03) U/L vs.(0.43 ± 0.01) U/L; β:(0.25 ± 0.01) U/L vs.(0.39 ± 0.02) U/L,(0.40 ± 0.04) U/L vs.(0.49 ± 0.05) U/L,all P < 0.05]; meanwhile the serum levels of Insulin receptor-α,β in patients with CHD were all significantly lower than those without CHD [α:(0.21 ± 0.02) U/L vs.(0.32 ± 0.03) U/L,(0.35 ±0.06) U/L vs.(0.43 ±0.01) U/L; β:(0.25 ±0.01) U/L vs.(0.40 ±0.04) U/L,(0.39 ±0.02) U/L vs.(0.49 ± 0.05) U/L,all P < 0.05].Conclusions The changes of serum level of insulin receptor may associate with coronary heart disease though hyperinsulinemia and insulin resistance.更多还原