【摘要】 目的探讨尤瑞克林对老年急性脑梗死(ACI)的治疗疗效及其对血清CRP、尿酸和血液流变学的影响。方法选择80例老年ACI患者,按入院顺序随机平均分为对照组和研究组各40例,两组患者入院后均给予常规ACI对症治疗,研究组患者在此基础上加用尤瑞克林注射液治疗。比较两组患者治疗后NIHSS评分及疗效;检测并比较两组患者治疗前后血清CRP、尿酸及血液流变学的变化。结果研究组患者治疗后NIHSS评分为(6.86±4.56)分,显著低于治疗前及对照组,治疗总有效率为87.5%,明显高于对照组的72.5%,差异有统计学意义(均P<0.05);研究组患者治疗后血清CRP和尿酸水平分别为(10.78±5.34)mg/L和(150.34±85.87)mg/L,明显低于对照组的(15.24±6.48)mg/L和(279.34±110.45)mg/L,组间差异有统计学意义(均P<0.05);研究组患者治疗后全血黏稠度及血小板聚集率分别为(4.01±0.31)mPa·s及(51.68±10.45)%,明显低于对照组的(5.02±0.32)mPa·s及(60.23±11.04)%,组间差异有统计学意义(均P<0.05)。结论尤瑞克林治疗老年急性脑梗死疗效显著,值得临床推广应用。更多还原

【Abstract】 Objective To evaluate the efficacy of Urinary Kallidinogenase in treatment of elderly patients with acute cerebral infarction and its effect on serum CRP,uric acid and hemorheology.Methods 80 cases of elderly patients with acute cerebral infarction were randomly divided into the two groups according to the order of admission.All patients were treated with conventional ACI symptomatic treatment while the study group used Urinary Kallidinogenase in addition.NIHSS score,serum CRP,uric acid and hemorheology and efficacy before and after treatment were detected.Results The NIHSS score of study group patients after treatment was significantly lower than that of study group patients before treatment and control group.The total effective rate of study group was 87.5%,which was significantly higher than that of control group(72.5%)(P<0.05).The serum CRP and uric acid levels of the study group(10.78±5.34)mg/L and(150.34±85.87)mg/L were significantly lower than that of the control group’(15.24±6.48mg/L and279.34±110.45mg/L)(P<0.05).The blood viscosity and platelet aggregation rate of study group patients after treatment were(4.01±0.31)mPa·s and(51.68±10.45)%,which were significantly lower than that of the control group(5.02±0.32mPa·s and 60.23±11.04%)(P<0.05).Conclusion The Urinary Kallidinogenase has a significant effect in treatment of elderly acute cerebral infarction which should be widely applied.更多还原