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利尿剂对高血压性心脏病心力衰竭患者发生心房颤动的影响

Diuretics affect the occurrence of atrial fibrillation in heart failure patients with hypertensive heart disease

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【作者】 姜巧珍蒋鹏陈相健

【Author】 JIANG Qiao-zhen;JIANG Peng;CHEN Xiang-jian;Department of Cardiology,Inner Mongolia People′s Hospital;Department of Cardiology,The First Affiliated Hospital of Nanjing Medical University;

【机构】 内蒙古自治区人民医院心内科南京医科大学第一附属医院心血管内科

【摘要】 目的探讨常规治疗与常规基础上加用利尿剂呋塞米治疗高血压性心脏病合并心力衰竭发生房颤患者的疗效。方法将300例高血压性心脏病心力衰竭患者,随机分为呋塞米组150例和对照组150例,对照组采用ACEI、肠溶阿司匹林、地高辛等常规治疗,呋塞米组在常规治疗基础上加用呋塞米80mg/d,观察治疗前后心率、动态心电图、左室射血分数等指标改善情况。结果两组治疗后显效率及总有效率均无统计学差异(P>0.05),但是呋塞米组与对照组心电图相比,显效率和总有效率有统计学意义(P<0.05)。结论在常规治疗基础上加用利尿剂呋塞米,可以抑制左心室心肌纤维化,改善舒张压。

【Abstract】 Objective To explore conventional treatment with on a regular basis and diuretic furosemide treatment of hypertensive heart disease with heart failure patients with atrial fibrillation.Methods 150patients in the control group were treated with conventional treatment of ACEI,aspirin and digoxin.The therapy group was treated with furosemide 80mg/d and conventional treatment.The indicators to improve the situation of the heart rate,Holter monitoring,left ventricular ejection fraction before and after treatment were observed.Results The treatment effective efficiency and total efficiency were not statistically different(P>0.05).The efficiency and total efficiency of furosemide group and the control group was statistically significant(P<0.05).Conclusion The conventional therapy and diuretic furosemide can inhibit left ventricular myocardial fibrosis and improve diastolic blood pressure.

【关键词】 利尿剂高血压心房颤动
【Key words】 DiureticsHypertensionAtrial fibrillation
【基金】 国家自然科学基金(81170220)
  • 【文献出处】 西部医学 ,Medical Journal of West China , 编辑部邮箱 ,2014年03期
  • 【分类号】R541.3
  • 【被引频次】6
  • 【下载频次】59
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