【摘要】 [目的]探讨非小细胞肺癌(NSCLC)患者血清periostin水平及其临床意义。[方法]采用酶联免疫吸附法(ELISA)检测102例NSCLC患者和40例良性肺部疾病患者血清periostin水平,并以35例健康人血清作为对照,比较不同分期、有无转移及术后1年复发与否的患者之间是否存在差异。[结果]NSCLC患者血清periostin水平[(38.6±18.7)ng/ml]显著高于健康对照者[(21.1±15.8)ng/ml,t=6.78,P<0.01]和良性肺部疾病者[(23.3±14.7)ng/ml,t=5.17,P<0.01]。Ⅲ/Ⅳ期患者血清periostin水平[(45.8±26.9)ng/ml]显著高于Ⅰ/Ⅱ期患者[(34.6±18.7)ng/mL,t=4.79,P<0.01]。有转移患者和术后1年内复发患者血清periostin水平分别高于无转移患者和无复发患者,差异均有统计学意义(t值分别为3.67,6.71,P<0.01)。[结论]NSCLC患者血清periostin水平有可能作为肿瘤转移和术后复发的预测指标。更多还原

【Abstract】 [Purpose] To investigate serum periostin level in patients with non-small cell lung cancer(NSCLC) and its clinical significance. [Methods] Patients with NSCLC(n=102),with benign lung disease(n=40) and healthy controls(n=35) were enrolled. Serum periostin level was measured by enzyme-linked immunosorbent assay(ELISA).The results were compared between patients with different tumor stages, with or without metastasis, with or without postoperative recurrence one year after surgery. [Results]Patients with NSCLC had higher periostin levels [(38.6±18.7)ng/ml]than patients with benign lung disease [(23.3±14.7)ng/ml,t=5.17,P<0.01] and the control group[(21.1±15.8)ng/ml,t=6.78,P<0.01].Serum periostin levels in stageⅢ/Ⅳpatients [(45.8±26.9)ng/ml]were significantly higher than those in stageⅠ/Ⅱpatients[(34.6±18.7)ng/ml, t=4.79,P<0.01].Serum periostin levels were higher in patients with distant metastasis or postoperative recurrence than those without(t=3.67 and 6.71,both with P<0.01).[Conclusion] Serum periostin level in patients with NSCLC might be a useful marker for predicting of metastasis and postoperative recurrence.更多还原