【摘要】 创伤是各种致伤因素造成的人体组织损伤和功能障碍,严重创伤导致全身炎症反应综合征(systemic inflammation response syndrome,SIRS)的发生。当机体受到创伤等严重打击后,体内相续启动一系列复杂的细胞生物学效应,包括应激信号的激活和传递、炎症反应失衡、各种有害因素的释放等。现代研究发现,创伤后患者体内p38MAPK(丝裂原激活的蛋白酶)的激活以及TNFα和IL-6等的表达水平都迅速上调,且都与创伤程度呈正相关。炎症反应在创伤的病理过程中发挥了重要的作用,也可能是部分创伤并发症(脓毒症、多器官衰竭、高代谢、深静脉血栓形成等)的诱因。TNFα、IL-1、IL-6、C-反应蛋白等均是创伤后炎症反应的敏感指标,能反应创伤患者的病情,评价炎症反应的严重程度。通过早期监测这些重要指标,采取适当的措施阻止炎症反应的进一步发展,以有效降低MODS发生率,减少创伤患者死亡率。本文就创伤后早期炎症因子TNF-a、IL-1、IL-6变化情况的研究进展做一综述。更多还原

【Abstract】 Trauma is the body tissue damage and dysfunction caused by various injury factors. Severe trauma leads to the occurrence of systemic inflammation response syndrome, SIRS. When the body is hit severely, for example trauma and etc., a series of complex effects of cell biology have been started in one’s body, including activation and transfer of stress signals, imbalance of inflammations, release of various harmful factors and etc. Modern research has found that the activation of p38MAPK and the expression levels of TNFα, IL-6 and etc. are increasing rapidly in patients’ body after trauma, and they are positively correlated with the degree of trauma. Inflammation plays an important role in the pathological process of trauma. It may also be the incentive of some trauma complications(sepsis, multiple organ failure, high metabolism, deep vein thrombosis, etc.). TNFα, IL-1, IL-6, C-reactive protein and etc. are sensitive indicators of post-traumatic inflammation. It is able to respond to the condition of trauma patient, and evaluate the severity of the inflammation. By early monitoring of these important indicators, taking appropriate measures to prevent the further development of inflammation, can effectively reduce the incidence of MODS and mortality of trauma patients. This article makes a summary on the research progress of changes of early post-traumatic inflammation cytokines TNF-a, IL-1, IL-6.更多还原