【摘要】 目的了解吸毒人群戊型肝炎病毒(HEV)感染情况,分析此人群高危行为方式与HEV感染之间的联系,为预防和控制戊型肝炎提供依据。方法采用横断面研究,从戒毒所和美沙酮门诊选择379名吸毒者,调查其吸毒行为方式、性行为特点,用ELISA法检测HEV-IgG抗体,分析吸毒人群戊型肝炎感染的影响因素。结果调查人群静脉注射吸毒的比例为52.8%,吸毒人群戊肝感染率为8.4%,40岁以上年龄组人群HEV感染率为16.3%,高于其他年龄组感染率(χ2=10.580,P=0.005);吸食海洛因的人群HEV感染率为12.0%,高于吸食冰毒人群的3.4%和吸食其他毒品人群的6.3%,差异有统计学意义(χ2=8.542,P=0.014);静脉吸毒人群的感染率为12.5%,高于非静脉吸毒人群的3.9%,差异有统计学意义(χ2=9.015,P=0.003)。结论静脉注射吸毒和年龄因素可能是吸毒人群HEV高感染的重要因素。更多还原

【Abstract】 Objective To investigate the prevalence hepatitis E virus(HEV) infection among drug abuse users(DUS), analyze the relation between high-risk behaviors and HEV infection, and provide the strategies for prevention of hepatitis E(HE). Methods A cross-sectional study was conducted and 379 DUS were enrolled from the drug rehabilitation center and methadone maintenance treatment clinic. The questionnaire included the drug using behaviors, the sexual behaviors among DUS. The HEV antibodies were tested with enzyme linked immunosorbent assay(ELISA). And the impact factors of the HEV infection were analyzed. Results52.8% participants were drug users by injection. The positive rate of HEV antibodies of DUS was 8.4%. The HEV infection rate in the group of 40~years was 16.3%, and it was significantly higher than that of others group(χ2=10.580, P=0.005). The positive rate of HEV antibodies in heroin abuse group(12.0%) was significantly higher than that the methamphetamine group(3.4%) and other drug using group(6.3%)(χ2=8.542, P=0.014). The rate of HEV infection of intravenous drug users(12.5%) was significantly higher than that of non-intravenous drug users(3.9%)(χ2=9.015, P=0.003). No significant association was found between HEV infection and sexual behavior. Conclusion Intravenous injection and age may be the risk factors of HEV infection among DUS.更多还原