【摘要】 目的系统评价白细胞介素10(IL-10)基因-1082G>A和-592C>A位点单核苷酸多态性与病毒性肝炎后肝纤维化遗传易感性的关系。方法以"liver cirrhosis"和"Interleukin-10"为主题词,辅以"liver Fibrosis"、"IL-10"、"肝硬化"等关键词,在PubMed、CNKI等中英文数据库检索相关文献。要求入选文献均为非相关的病例对照研究,以OR值为效应指标,利用Review Manager5.2和Stata12软件进行合并分析、亚组分析、异质性检验、敏感性分析,最后用漏斗图和Egger检验对发表偏倚进行评估。结果最终选定14篇文献,累计病例1 086例,对照1 227例。合并分析显示:IL-10-1082G>A位点等位基因和基因型与病毒性肝炎后肝纤维化患病风险无关联(等位基因比较:OR=0.86,95%CI:0.71~1.03;显性模型:OR=0.81,95%CI:0.63~1.04;隐性模型:OR=0.87,95%CI:0.57~1.31;纯合子比较:OR=0.86,95%CI:0.54~1.36)。IL-10-592C>A位点去除导致异质性的数据后,合并分析结果也显示其多态性与肝纤维化无关联。结论 IL-10基因多态性与病毒性肝炎后肝纤维化遗传易感性无关联。更多还原

【Abstract】 Objective The study was conducted to systematically evaluate the correlation between single nucleotide polymorphism at positions-1082G>A and-592C>A of interleukin 10 gene(IL-10) and genetic susceptibility to liver fibrosis after viral hepatitis.Methods Relevant literatures were accessed from English and Chinese databases such as PubMed and CNKI by searching "liver cirrhosis" and "Interleukin-10" in titles and "liver fibrosis", "IL-10", and "liver cirrhosis" as keywords; only literatures on independent case control studies were included. OR was used as the effect indicator, and Review Manager5.2 and Stata12 were utilized for combined analysis, subgroup analysis, heterogeneity test, and sensibility analysis. Finally, funnel plot and Egger test were adopted to evaluate the publication bias. Results Fourteen literatures were selected, including a total of 1086 cases and 1227 controls.Combined analysis showed that allele and genotype at position IL-10-1082G>A were not associated with the risk of liver fibrosis after viral hepatitis(comparison of allele: OR=0.86, 95% CI: 0.71-1.03; dominant model: OR=0.81, 95% CI: 0.63-1.04; recessive model: OR=0.87, 95% CI: 0.57-1.31; comparison of homozygote: OR=0.86, 95% CI: 0.54-1.36). After removal of heterogeneitycausing data at position IL-10-592C>A, combined analysis also indicated no correlation between the gene polymorphism and liver fibrosis. Conclusion IL-10 gene polymorphism is not associated with genetic susceptibility to liver fibrosis after viral hepatitis.更多还原