【摘要】 目的了解耐多药肺结核患者(MDRTB)临床疗效及其转归,以进一步提高对注射期重要性的认识,探讨MDRTB患者管理办法。方法选取2009年10月至2011年1月南通市第六人民医院收治的经南通市疾病预防控制中心和南通市第六人民医院药物敏感试验证实的MDRTB患者76例,分为注射期末阳性组、阴性组和未查组,观察3组间临床疗效、不良反应、转归等。结果注射期末痰菌阴性组痰菌阴转率、病灶吸收率、空洞闭合率均明显高于痰菌阳性组和未查组,而不良反应发生率在3组间差异无统计学意义。涂阴组治愈率明显高于涂阳组和未查组,差异有统计学意义(χ2=23.276,P<0.05)。结论 MDRTB患者中,注射期末痰菌阴性组临床疗效及转归明显好于涂阳组和未查组。重视规范MDRTB患者注射期治疗及定期监测,加强督导管理,可提高治愈率。更多还原

【Abstract】 Objective To investigate clinical effect and sequelae of MDR-TB patients to deepen the understanding of importance of injection, and discuss methods of managements. Methods Chose 76 MDR-TB patients from 6th People’s Hospital in Nantong from October 2009 to January 2011, and diagnosed by NTCDC and 6th People’s Hospital, divided them into positive group, negative group and non-check group at the end of injection period, and observed clinical effect, adverse reactions and sequelae. Results At the end of injection period, conversion rate, focus absorption rate and cavity closure rate of negative group were significantly higher than positive group and non-check group, while the adverse reactions were opposite. The cure rate of negative group was significantly higher than positive group and non-check group(χ2=23.276, P<0.05). Conclusion The clinical effect and sequelae of MDR-TB patients with sputum smear negative at the end of injection period are better than positive and non-check group. Taking standard treatment seriously, surveying termly and intensifying management can raise curative effect.更多还原