【摘要】 目的采用白芍总苷对嗜酸性粒细胞增高的湿疹患者进行治疗,观察疗效及对嗜酸性粒细胞的影响,并了解其安全性。方法将嗜酸性粒细胞增高的湿疹患者随机分为观察组和对照组,各40例,均使用美能片、盐酸西替利嗪和相同的外用药治疗,观察组同时使用白芍总苷,8周后观察其疗效及嗜酸性粒细胞的变化,并通过临床症状及肝肾功评估其安全性。结果治疗8周后观察组的有效率及痊愈率均明显高于对照组(P<0.05)。治疗前后,观察组的EOS(eosinophil)水平变化与对照组的EOS水平变化比较差异有统计学意义(P<0.05)。治疗结束时两组均未发现明显不良反应。结论白芍总苷可以使嗜酸性粒细胞增高的湿疹患者的EOS明显下降,症状明显缓解,疗效优于对照组,且无明显不良反应。更多还原

【Abstract】 Objective Eczema patients with eosinophilia were treated with total paeony glycosides, and the effectiveness of the treatment as well as its effect on eosinophil granulocytes were observed to determine the safety of the treatment. Methods Eczema patients with eosinophilia were randomly divided into an observation group(40 cases) and a control group(40 cases); both groups were treated with SNMC tablet, cetirizine hydrochloride, and the same topical medication; the observation group was also treated with total paeony glycosides. After eight weeks of treatment, effectiveness of the treatment and changes in eosinophile granulocytes were observed and clinical symptoms and liver/renal functions of the patients were assessed to evaluate the safety of the treatment. Results After 8 weeks of treatment, effective rate and recovery rate of the observation group were significantly higher than those of the control group(P<0.05). Statistically significant differences were observed in changes in EOS(eosinophil) level before and after the treatment between the observation group and the control group(P<0.05). No adverse effect was reported by the end of the treatment in either group. Conclusion Total paeony glycosides can significantly decrease EOS level and relieve symptoms in eczema patients with eosinophilia; the glycosides are more effective than the control group and cause no obvious toxic side effects.更多还原