【摘要】 背景:针对骨质疏松症伴发骨缺损疾病的传统治疗方法,诸如自体骨移植、异体骨移植、生物材料植入均有明显的局限性。以脂肪干细胞为种子细胞,采用再生医学的方法,为骨质疏松症骨缺损的修复提供了一种新的途径。目的:就骨质疏松症的发病机制及其对骨缺损修复的影响、信号通路对脂肪干细胞成骨分化的调控、脂肪干细胞修复骨质疏松症骨缺损的可行性等方面作一总结。方法:应用计算机检索中国期刊全文数据库(CNKI)和PubMed数据库中1998年1月至2014年9月相关文献。在标题和摘要中以"脂肪干细胞,骨质疏松症,骨缺损,成骨分化,骨再生"或"adipose-derived stem cells,osteoporosis,bone defect,osteogenic differentiation,bone regeneration"为检索词进行检索,重点对77篇文章进行分析。结果与结论:近年来,脂肪干细胞已广泛应用于再生医学的研究。随着有关学科如再生医学、组织工程学、分子生物学、材料学的发展,对脂肪干细胞成骨分化调控机制的研究不断深入,脂肪干细胞复合生物支架构建组织工程骨为解决骨质疏松症骨缺损修复难题,提供了一种新的思路和方法,具有良好的发展前景。更多还原

【Abstract】 BACKGROUND: The traditional treatment methods for osteoporosis accompanied by bone defects, such as autogenous bone graft, allograft, biomaterial implants, have significant limitations. The regenerative medicine approach using adipose-derived stem cells as seed cells offers a new way for the repair of bone defects following osteoporosis. OBJECTIVE: To review the pathogenesis of osteoporosis and its impacts on the repair of bone defects, the signal pathway regulation of osteogenic differentiation of adipose-derived stem cells, and the feasibility of adipose-derived stem cells for repairing osteoporotic bone defects. METHODS: A computer-based online search of CNKI database and PubMed database was performed to retrieve the relevant articles published from January 1998 to September 2014 with the key words of "adipose-derived stem cells, osteoporosis, bone defect, osteogenic differentiation, bone regeneration" in Chinese and English, respectively. Finally 77 articles were included for review after deleting unrelated and repetitive ones.RESULTS AND CONCLUSION: In recent years, adipose-derived stem cells have been widely used in regenerative medicine research. With the development of relevant disciplines such as regenerative medicine, tissue engineering, molecular biology, and material science, in-depth studies on regulatory mechanisms of osteogenic differentiation of adipose-derived stem cells have been developed. Adipose-derived stem cells combined with biological scaffolds for construction of tissue-engineered bones provides a new way to repair osteoporotic bone defects.更多还原