【摘要】 目的:评价经胰血管留置导管持续区域灌注生长抑素和抗生素治疗重症急性胰腺炎(SAP)的疗效。方法:将29例SAP患者分为区域灌注及早期中药治疗组(13例)和常规给药组(16例)。区域灌注及早期中药治疗组经股动脉超选择插管至胰腺坏死的供血动脉留置导管,用微泵持续24小时灌注生长抑素及抗生素,症状体征消失后拔管。常规给药组用静脉输注药物,药物用量及剂量完全同区域灌注组。结果:灌注组治疗后48小时腹部体征明显改善,腹痛减轻,7~12天症状全部消失,病情无复发,疗程平均20天,均痊愈出院。常规给药组治疗后5~7天见腹部体征改善,病情有反复,疗程45天~4个月,平均57天。常规给药组出现严重并发症13例次,死亡4例。结论:经胰血管置管持续区域灌注生长抑素及抗生素及早期中药治疗SAP疗效好,病程短,并发症少,应推广应用。更多还原

【Abstract】 Objective: To evaluate the therapeutic efficacy of continous regional intra-arterial infusion( CRI) of sandostatin and Antibiotics in patients of severe acute pancreatitis( SAP). Methods: Twenty nine cases of SAP patients were randomly divided in-to two groups.Group of CRI,13 cases and control group,16 cases. Seldingers method was used in brief,placing a catheter in the pancreatic regional artery such as gastropyloric artery,irrigating the inflamed area of the pancreas,and infusing sandostatin and antibiotics to control inflammation and prevent secondary infection by continuous pumping for 24h. Results: Abdominal sings and pain were apparently relieved after 24h of treatment,disappeared in 7-12days. Twelve cases were cured. Clinical Manifestations in control group lasted much longer compared with CRI group,after 5-7days of the treatment,abdominal signs Began subsiding. Conclusion: Continous regional intra-arterial infusion for the treatment of severe acute pancreatitis can prevent The development of pancreatic infection and big cut the course of treatment.更多还原