【摘要】 细胞迁移在发育、伤口愈合、炎症反应和肿瘤转移等多种病理生理过程中发挥重要作用。细丝蛋白A(filamin A,FlnA)是一种在各组织细胞中广泛表达的微丝结合蛋白,其表达异常导致细胞迁移功能障碍。该文回顾了相关的文献,首先介绍生理情况下细丝蛋白A的功能,接着介绍细丝蛋白A基因突变和表达异常导致的多种遗传性疾病及其与肿瘤转移的关系,突出细丝蛋白A对迁移的影响在这些疾病发病中的作用,最后深入探讨了细丝蛋白A影响细胞迁移和黏附的可能机制。更多还原

【Abstract】 Cell migration is essential for development, tissue remodeling and wound healing, and is abnormal in many pathological states. Filamin A is an actin-binding protein and is widely expressed in various cell types. Mutations in filamin A gene are the cause of a wide range of genetic diseases, while abnormality in filamin A expression is resposible for cancer metastasis. Filamin A regulates cytoskeleton rearragement and palys a pivotal role in cell shape determination. Depletion of filamin A leads to obvious cell migration defects. In this review, we discuss the implication of filamin A in genetic diseases and cancer metastasis, emphasizing the impact of cell migration defects on these diseases. Further more, we discuss the role of filamin A on cell migration and its underlying mechanism.更多还原