【摘要】 目的观察5%咪喹莫特乳膏预防二氧化碳(CO2)激光治疗后宫颈尖锐湿疣(CA)的复发情况和对人乳头瘤病毒(HPV)的清除情况。方法对94例宫颈CA(HPV阳性)患者先进行CO2激光治疗,再随机分为观察组(46例)和对照组(48例),观察组给予5%咪喹莫特乳膏涂布宫颈及阴道后穹窿,每周2次,共12周。随访24周。对照组在CA复发时只进行激光治疗。两组患者均在CO2激光治疗后第12周、第24周进行HPV复查。结果两组在术后第12周、24周的疣体复发情况比较差异有统计学意义(P均<0.05),观察组的复发率低于对照组。在12周及24周时观察组HPV清除率较对照组高,两者比较差异有统计学意义(P均<0.05)。结论在CO2激光治疗后,5%咪喹莫特乳膏能有效预防宫颈尖锐湿疣的复发,对HPV有良好的清除作用。更多还原

【Abstract】 Objective To investigate the prevention effect of 5%imiquimod cream on relapse of cervical condyloma acuminatum(CA)and clearance of human papillomavirus(HPV)after carbon dioxide laser surgery.MethodsNinety-four women with HPV positive cervical CA were treated with carbon dioxide surgery,and then were randomly divided into treatment group(46cases)and control group(48cases).The treatment group were applied with5%imiquimod cream on the cervix and the posterior fornix twice a week for 12 weeks and followed up for 24 weeks.The control group only received the CO2 laser treatment when CA relapsed.All the patients were tested HPV at 12 and 24weeks after the first CO2 laser surgery.Results There were significant differences in recurrence rate between the two group at 12 and 24weeks after the CO2 laser treatment(both P<0.05).The recurrence rate of the treatment group was lower than that of the control group.There were significant differences in HPV clearance rate between the two group at 12 and 24weeks after treatment(both P<0.05).The HPV clearance rate of the treatment group was higher than that of the control group.Conclusion Topical application of 5%imiquimod cream is effective to prevent relapse of cervical condyloma acuminatumafter removing the warts by carbon dioxide.It is a good way to clear HPV infection.更多还原