【摘要】 目的了解吉林省社区糖尿病患者血脂异常的特征,为糖尿病患者血脂异常的管理提供依据。方法基于2012年吉林省成人慢性病患病率及危险因素调查,采用多阶段分层随机整群抽样方法,对其中检出的1825名糖尿病患者进行问卷调查(年龄、性别、近一年慢性病患病情况)、血生化指标检测(血糖、总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白)及身体测量(身高和体重)。结果糖尿病患者共1825人,其中男性883人(48.4%),女性942人(51.6%),平均年龄为(55.73±10.27)岁。TG、TC、LDL-C和HDL-C的平均水平分别为2.17、5.17、3.10和1.20mmol/L,女性患者TC、LDL-C和HDL-C水平均高于男性(P<0.001)。血脂异常率为66.9%(男性为69.0%,女性为65.0%)。男性血脂异常率随年龄的增加而降低(P<0.001),女性随年龄增长而升高(P<0.001)。18岁~、35岁~、45岁~年龄组男性血脂异常率高于女性(P<0.05、P<0.001、P<0.001),而55岁~、65~79岁则低于女性(P<0.05);超重(71.8%)及肥胖(75.8%)者血脂异常率高于BMI正常者(55.2%)(P<0.001)。TG、TC、LDL-C及HDL-C异常率分别为47.8%、19.2%、14.5%和29.2%;糖尿病患者中27.1%为二项血脂指标异常,17.4%为TG升高合并HDL-C降低,其次15.9%为单纯TG升高。结论吉林省社区糖尿病患者的TC、TG及LDL-C平均水平均高于一般人群,18~54岁男性、55岁及以上女性与超重或肥胖的糖尿病患者的血脂异常率较高,血脂异常以混合型为主,TG升高合并HDL-C降低较多。更多还原

【Abstract】 Objective To investigate the pattern of dyslipidemia in patients with diabetes mellitus in Jilin province communities,and to provide a theoretical basis for the management of dyslipidemia among patients with diabetes. Method Based on the prevalence and risk factors of chronic diseases survey among adults in Jilin Province 2012 used multistage stratified random sampling design,a total of 1825 community residents aged 18- 79 years-old with diabetes mellitus in 9 districts of Jilin Province undergo the survey with questionnaire( age,gender,history of chronic disease in the past one year),blood index detection( blood glucose, total cholesterol high density lipoprotein cholesterol,low density lipoprotein cholesterol and triglycerides),and anthropometric( height and weight). Result Among 1825 patients with diabetes,883 males( 48. 4%),942 females( 51.6%); the mean age was( 55.73 ± 10.27) years old. The mean values of TG,TC,LDL-C and HDL-C were 2. 17,5. 17,3. 10 and 1. 20 mmol /L,the mean values of TC、LDL-C and HDL-C of female were higher than male( P < 0. 001). The prevalence of dyslipidemia was 66. 9%( 69. 0% in male and 65. 0% in female). The prevalence of dyslipidemia in male was decreased with increasing age( P < 0. 001),the prevalence of dyslipidemia in female was increased with age( P < 0. 001). In age groups of 18-,35- and 45- years,the prevalence of dyslipidemia in male was higher than female( P < 0. 05,P < 0. 001,P < 0. 001),however,it was lower than female in 55-and 65- 79 years old groups( P < 0. 05). The prevalence of dyslipidemia of overweight( 71. 8%) and obesity( 75.8%) was higher than normal subjects. Among patients with diabetes,19. 2% had high total cholesterol,47. 8% had high triglyceride,14. 5% had high levels of low-density lipoprotein cholesterol,29. 2% had low high-density 1ipoprotein cholesterol. The proportion of diabetic patients two serum lipid values outside of clinical target were 27. 1%,the most prevalent dyslipidemia pattern among diabetic patients was a combination of TG above goal with HDL-C below target,which was observed in 17. 4 % of the patients. The second most common pattern of dyslipidemia was isolated TG increase,which was observed in 15. 9% of the patients. Conclusion The mean values of TG,TC,LDL-C and HDL-C among community residents with diabetes mellitus in Jilin province were higher than the general population. The prevalence of dyslipidemia in male aged 18- 54 years,female aged 55 years and above and overweight or obesity was high; the most prevalent dyslipidemia pattern among diabetic patients was a combination of TG above goal with HDL-C below target.更多还原