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2010—2012年度季节性流行性感冒疫苗对6~59月龄儿童保护效果的病例对照研究

Case-control study on seasonal influenza vaccine effectiveness among children from 2010 to 2012

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【作者】 傅传喜贺晴许建雄杨琼英张春焕胡文穗董智强王鸣

【Author】 FU Chuan-xi;HE Qing;XU Jian-xiong;YANG Qiang-ying;ZHANG Chun-huan;HU Wen-sui;DONG Zhi-qiang;WANG Ming;Guangzhou Center for Disease Control and Prevention;

【机构】 广州市疾病预防控制中心

【摘要】 目的评价2010—2012年度季节性流行性感冒疫苗(流感疫苗)对儿童的上市后保护效果。方法选择2010—2012年度6~59月龄的实验室诊断流感病例为病例组,在儿童预防接种信息系统中随机选择健康儿童为对照组,进行1∶2匹配的病例对照研究,采用条件Logistic回归计算保护效果。结果研究中共纳入1 255组研究对象。2010—2011和2011—2012年度,流感疫苗对6~59月龄儿童完全免疫的保护效果分别为73.2%(95%可信限(CI):52.2~85.0)和52.9%(95%CI:42.1~61.7),对6~35月龄儿童的保护效果优于36~59月龄儿童,完全免疫的保护效果优于部分免疫。流感疫苗的保护效果从1~3月的68.9%(95%CI:57.5~77.2)衰减至4~6月的48.4%(95%CI,33.8~59.7)。结论流感疫苗对6~59月龄儿童具有一定的保护效果,儿童接种疫苗后可以减少52.9%~73.2%的流感病例,建议儿童每年及时进行全程免疫。

【Abstract】 Objective To estimate the effectiveness of seasonal influenza vaccine during 2010 to 2012 seasons. Metho- d s The 1∶ 2matched case-control study was conducted among children aged 6-59 months. The influenza cases from surveillance sites in Guangzhou were laboratorial confirmed during the study periods. The healthy controls were randomly selected from children aged 6 to 59 months in the Children’s Expanded Programmed Immunization Administrative Computerized System. Vaccine effectiveness was analyzed by conditional logistic regression. Results The vaccination information for 1 255 sets of subjects were analyzed in 2 influenza seasons in Guangzhou,China. Protective rate for vaccination during the 2010— 2011 and 2011—2012 seasons for children 6- 59 months were 73. 2%( 95% confidence interval( CI) : 52. 2- 85. 0) and 5 2. 9%( 95% CI: 42. 1- 61. 7),respectively. Full vaccination provided more protective effect than partial vaccination. The VE decreased from 68. 9%( 95% CI: 57. 5- 77. 2) in 1-3 months after vaccination to 48. 4%( 95% CI: 33. 8- 59. 7) in 4- 6 months after vaccination. Conclusions This post-licensing study of VE found that moderate protection against influenza for vaccinated children aged 6 to 59 months. Annual,full and timely vaccination should be encouraged for children.

【基金】 广东省省部产学研结合项目(2012B091100045);广州市对外科技合作专项(2012J5100005)
  • 【文献出处】 微生物学免疫学进展 ,Progress in Microbiology and Immunology , 编辑部邮箱 ,2014年03期
  • 【分类号】R186
  • 【被引频次】11
  • 【下载频次】187
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