【摘要】 建立了顶空-气相色谱法检测琥珀酸美托洛尔中残留溶剂(丙酮和异丙醇)的测定方法.被测样品的各个组分在非极性弹性石英毛细管柱上能有效分离;在0.001~0.300 mg/m L浓度范围内,线性相关系数R≥0.9990;加标回收率为90.73%~104.80%,相对标准偏差为0.76%~11.85%(n=5),方法的检出限为2.00μg/m L.该方法检测琥珀酸美托洛尔中的残留溶剂重现性好,定量准确,便于操作.更多还原

【Abstract】 A method is set up which detects residual solvents that remains in metroprolol succinate by headspace chromatography. External reference method and headspace auto-sample injection is used through nonpolarity flexibility quartz capillary chromatographic column and get a good effect. The linear range is from 0. 001 to 0. 300 mg / m L,the correlation coefficient R ≥0. 9990;standard solution spiked levels from 0. 001 to 0. 300 mg / m L,the recovery rate is 90. 73% to 104. 80%,and the relative standard deviation is from 0. 76% to 11. 85%,the detection limit of method is 1. 00 μg / m L. This method of determining metroprolol succinate has a good reproducibility,nice quantitative and the operation is very easy.更多还原