【摘要】 目的:了解芜湖市宫颈疾患妇女中人乳头瘤状病毒(human papillomavirus,HPV)感染情况及HPV基因型别的主要分布状况。方法:对1 107例宫颈病变患者宫颈液基细胞学标本进行21种HPV基因型检测。结果:1 107例标本中共检出HPV阳性230例,总感染率为20.78%(230/1 107),其中高危型HPV感染者173例,占75.22%(173/230);低危型HPV感染者40例,占17.39%(40/230);高低危混合HPV感染者17例,占7.39%(17/230)。除未检出HPV高危型35型、51型和低危型43型,其余各型均有检出。HPV各型别的感染率中HPV16最高为28.26%(65/230);其他型别感染率在前五位的从高到低依次为HPV58(23.04%,53/230)、HPV33(12.61%,29/230)、HPV52(11.74%,27/230)、HPV6和53,后两型别的感染率相同均为9.57%(22/230)。在各年龄组受试者中,>60岁妇女HPV感染率最高,为42.86%,其次为≤20岁(27.78%),各年龄组受试者之间HPV感染率差异无统计学意义(P>0.05)。结论:芜湖市宫颈病变患者中人乳头状瘤病毒感染以高危型为主,HPV16、58、33、52、6和53型可能是该市妇女宫颈病变患者较易感染的主要型别。更多还原

【Abstract】 Objective: To investigate the human papillomavirus( HPV) infection in women living in Wuhu areas with cervical lesions and its genotype distribution. Methods: Cytology test was performed in 21 HPV genotypes detected in the cervical mucus of 1 107 patients with cervical lesions. Results: In1 107 cases,positive HPV was found in 230( 20. 78%),in which high-risk HPV infection was seen in 173( 75. 22%; 173 /230),low-risk in 40( 17. 39%; 40 /230) and potential high-low-risk HPV in 17( 7. 39%; 17 /230). The most genotypes were detected in the total cases except for high-risk HPV 51 and HPV35 as well as low-risk HPV43. HPV16 infection was the highest( 28. 26%; 65 /230),followed by HPV58( 23. 04%; 53 /230),HPV33( 12. 61%; 29 /230),HPV52( 11. 74%; 27 /230) and HPV6( 9. 57%; 22 /230) that was equal to HPV53. Highest HPV infection was found in women over 60 years of age( 42. 86%),and lowest in those of 20 years or under( 27. 78%),yet no statistical significance was found within different ages( P >0. 05). Conclusion: High-risk HPV infection was prevalent in women in Wuhu areas with cervical lesions,and the infection was associated in general with genotype 16,58,33,52,6 and 53.更多还原