【摘要】 目的:了解我院就诊的成人慢性咳嗽患者变应原分布情况及评价SPT的应用价值。方法:回顾性分析132例慢性咳嗽患者皮肤点刺试验结果,并比较不同性别、不同年龄段慢性咳嗽患者SPT阳性率结果。结果:①132例慢性咳嗽患者SPT结果阳性率为75.76%。不同性别慢性咳嗽患者SPT阳性率,经比较差异无统计学意义(χ2=0.530,P=0.466)。②14种过敏原中,SPT阳性率最高的为粉尘螨,户尘螨、蟑螂、花粉(包括蒿属花粉、葎草花粉、梧桐花粉、白桦花粉、玉米花粉)、真菌(包括酵母菌、青霉菌)、棉絮、猫毛、狗毛依次降低,最少为羽毛。尘螨点刺试验阳性率与其他过敏原相比,差异有高度统计学意义(χ2=715.334,P=0.000)。③不同年龄段慢性咳嗽患者SPT阳性率结果差异有统计学意义(χ2=10.305,P<0.05)。除中年人(45~59岁)与老年人(60~75岁)SPT阳性率之间的差异有统计学意义外,其余两两之间的差异均无统计学意义,可认为中年人SPT阳性率高于老年人。结论:粉尘螨和户尘螨是我院就诊的成人慢性咳嗽患者最常见的变应原,慢性咳嗽患者应尽早行过敏原皮肤点刺试验,其对慢性咳嗽患者的病因诊断有重要意义,并为舌下脱敏治疗提供临床依据。更多还原

【Abstract】 Objective: To investigate the distribution of allergens in adult patients with chronic cough in Yijishan Hospital,and evaluate the application value of skin prick testing( SPT). Methods: SPT results were retrospectively summarized in 132 adult cases of chronic cough,and positive SPTs were compared in genders and ages. Results: ①Positive SPT was found in 75. 76% of the 132 patients,yet there was no statistical significance in ages( χ2= 0. 530,P = 0. 466); ②Fourteen allergens detected via SPT stood from the highest to the lowest by Dermatophagoides farinae,house dust mites,roaches,pollen( including artemisia pollen,the pollen of humulus scandens,phoenix tree pollen,birch pollen,corn pollen),fungi( including yeast,penicillium),cotton fibre,dog hair,cat hair,and feathers. The difference was significant between the positive result of SPT from dust mites and other allergens( χ2= 715. 334,P = 0. 000); ③There was statistical significance in positive SPT findings for patients with different age,especially for age range of 45- 59 and 60- 75years( χ2= 10. 305,P < 0. 05). Conclusion: Dermatophagoides farinae and house dust mites appear the most common allergens resulting in chronic cough in adult patients seeking therapy in our hospital. Early SPT may contribute to final diagnosis and supply evidence for desensitization therapy under the tongue.更多还原