【摘要】 目的研究两种粪便生物标记物乳铁蛋白、钙卫蛋白诊断溃疡性结肠炎(ulcerative colitis,UC)活动性的价值。方法选择确诊的UC患者72例作为研究组,60例经结肠镜检查均正常的患者作为对照组,留取结肠镜检查3 d内的粪便样本5~10 g,应用ELISA方法进行粪便乳铁蛋白、钙卫蛋白检测。结果粪便乳铁蛋白、钙卫蛋白水平在缓解组和对照组之间比较差异均无统计学意义(P>0.05);活动组分别与缓解组和对照组比较差异均有显著统计学意义(P<0.01);活动期各组之间相互比较差异均有统计学意义(P<0.01)。粪便乳铁蛋白、钙卫蛋白水平与UC内镜分级标准呈正相关(r=0.873;0.891,P<0.01)。结论粪便乳铁蛋白、钙卫蛋白检测能够较准确地诊断UC活动期和缓解期,对临床治疗有指导作用。更多还原

【Abstract】 Objective To investigate the diagnostic value of lactoferrin and calprotectin in ulcerative colitis(UC).Methods Sixty patients as controls and 72 patients with UC as UC group were collected in this study. All patients were collected 5 ~ 10 g feces sample after colonoscopy during three days. An enzyme linked immunosorbent assay was used to determine fecal lactoferrin and calprotectin. Results The difference of fecal lactoferrin and calprotectin concentration between inactive UC group and control group was not statistically significant(P > 0. 05); there was statistical significance of fecal lactoferrin and calprotectin concentration between active UC group and inactive UC group(P < 0. 01);significant difference existed in active grades of UC each other(P < 0. 01). The endoscopic grade of disease activity was related with fecal lactoferrin and calprotectin concentration(r = 0. 873; 0. 891,P < 0. 01). Conclusion Patients with active or inactive UC were diagnosed by fecal lactoferrin and calprotectin detection. The directions of fecal lactoferrin and calprotectin to clinical medication of UC has gained better curative effect.更多还原