【摘要】 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备HPLC等方法从海洋真菌菌核青霉Penicillium sclerotiorum FS50中分离纯化了9个化学成分,通过化合物波谱学数据及理化性质确定它们的结构分别为penicilazaphilone B(1)、sclerotioramine(2)、紫檀醇(3)、亚油酸甘油酯(4)、(3β,5α,6β,22E)-6-methoxyergosta-7,22-diene-3,5-diol(5)、啤酒甾醇(6)、对羟基苯乙酮(7)、酪醇(8)、邻苯二甲酸二(2-乙基)己酯(9)。其中化合物3为首次从青霉属中分离得到,化合物2、4、5、6、8、9为首次从菌核青霉中分离得到。更多还原

【Abstract】 Nine chemical constituents were separated and purified from marine-derived fungus Penicillium sclerotiorum FS50 by silica gel column chromatography,Sephadex LH-20 column chromatography and semi-preparative HPLC. On the basis of spectral data and physicochemical properties,their structures were determined as penicilazaphilone B( 1),sclerotioramine( 2),pterocarpol( 3),glycerol monolinoleate( 4),( 3β,5α,6β,22E)-6-methoxyergosta-7,22-diene-3,5-diol( 5),cerevisterol( 6),4-hydroxyacetophenone( 7),tyrosol( 8) and di-( 2-ethyl)-hexylphthalate( 9). Compound 3 was isolated from the genus Penicillium for the first time,compounds 2,4,5,6,8,9 were isolated from the species for the first time.更多还原