【摘要】 从人参内生球毛壳菌株RSQMK-9的发酵培养物中提取分离得到14个代谢产物,通过波谱分析鉴定其结构分别为麦角甾醇(1)、4,6,8,22-四烯-3-酮-麦角甾烷(2)、啤酒甾醇(3)、9(11)-去氢麦角甾醇过氧化物(4)、alternariol(5)、大黄素甲醚(6)、3-吲哚甲酸(7)、2,3,4-三甲基-5,7-二羟基-2,3-二氢苯并呋喃(8)、2-氨基苯甲酰胺(9)、2-氨基苯甲酸(10)、3-甲基苔色酸(11)、甘露醇(12)、chaetoglobosin A(13)及5’-epichaetovirdin A(14)。这些化合物均为首次从人参内生球毛壳菌中发现,而且化合物6为首次从该属真菌中分离到。海虾致死试验结果显示:10μg/mL浓度下,化合物13和14对丰年虾的致死率分别为83.4%和54.3%。更多还原

【Abstract】 14 metabolites,namely ergosterol( 1),ergosta-4,6,8,22-tetraen-3-one( 2),cerevisterol( 3),9( 11)-dehyoergosterol peroxide( 4),alternariol( 5),physcion( 6),Indole-3-carboxylic acid( 7),2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran( 8),anthranilamide( 9),anthranilic acid( 10),3-methylorsellinic acid( 11),mannitol( 12),chaetoglobosin A( 13) and 5’-epichaetovirdin A( 14) were firstly isolated from the extract of fermentation broth of fungus Chaetomium sp. RSQMK-9,an endophyte of Panax ginseng. Their chemical structures were elucidated by spectroscopic methods,compound 6 was firstly isolated from the genus Chaetomium. The toxicities of compounds 13 and 14 were tested by brine shrimp bioassay,and the mortality rates of compound 13 and 14 against Artemia salina larvae were 83.4% and 54. 3%,respectively,at the concentration of 10 μg /mL.更多还原