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降香中的酚性化合物

Phenolic Compounds from the Heart wood of Dalbergia odorifera T. Chen

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【作者】 王昊梅文莉杨德兰钟惠民戴好富

【Author】 WANG Hao;MEI Wen-li;YANG De-lan;ZHONG Hui-min;DAI Hao-fu;College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology;Key Laboratory of Biology and Genetic Resources of Tropical Crops,Ministry of Agriculture,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences;Hainan Key laboratory for research and development of natural products from Li folk medicine;

【机构】 青岛科技大学化学与分子工程学院中国热带农业科学院热带生物技术研究所,农业部热带作物生物学与遗传资源利用重点实验室海南省黎药资源天然产物研究与利用重点实验室

【摘要】 从降香(Dalbergia odorifera)中分离得到10个酚性化合物,运用波谱学方法分别鉴定为dalbergin(1),7-O-methylvestitol(2),syringaresinol(3),3,7-dihydroxy-2’,4’-dimethoxyisoflavanone(4),3’-hydroxy-8-methoxyvestitol(5),2’,6-dihydroxy-4’-methoxy-2-arylbenzofuran(6),3’-O-methylviolanone(7),pinocembrin(8),prunetin(9),mucronulatol(10)。其中化合物1具有乙酰胆碱酯酶抑制活性,化合物2~5为首次从降香中分离得到。

【Abstract】 Ten phenolic compounds were isolated from Dalbergia odoriferae and purified by repeated column chromatography on silica and Sephadex LH-20 gel,and their structures were identified as dalbergin( 1),7-O-methylvestitol( 2),syringaresinol( 3),3,7-dihydroxy-2’,4’-dimethoxyisoflavanone( 4),3’-hydroxy-8-methoxyvestitol( 5),2’,6-dihydroxy-4’-methoxy-2-arylbenzofuran( 6),3’-O-methylviolanone( 7),pinocembrin( 8),prunetin( 9),and mucronulatol( 10)by spectral analysis. Among these isolates,compound 1 exhibited inhibitory activities against acetylcholinesterase( AChE),and compounds 2-5 were isolated from this plant for the first time.

【基金】 公益性行业(农业)科研专项经费项目(201303117);国家科技支撑计划课题项目(3013BAI11B04)
  • 【文献出处】 天然产物研究与开发 ,Natural Product Research and Development , 编辑部邮箱 ,2014年06期
  • 【分类号】R284.1
  • 【被引频次】15
  • 【下载频次】314
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