【摘要】 采用硅胶、Sephadex LH-20凝胶、Toyopearl HW-40凝胶及Diaion HP-20树脂等色谱方法从云南丽江棉毛橐吾中分离得到化合物18个,通过理化手段及波谱技术分别鉴定为:呋喃艾里莫芬-14β,6α-内酯(1)、β-谷甾醇(2)、惕格酸(3)、棕榈酸(4)、十九烷酸甲酯(5)、艾里莫芬-7(11)-烯-12,8α(14β,6α)-二内酯(6)、8β-甲氧基艾里莫芬-7(11)-烯-12,8α(14β,6α)-二内酯(7)、1-O-十六烷酰基甘油酯(8)、8β-羟基艾里莫芬-7(11)-烯-12,8α(14β,6α)-二内酯(9)、对羟基桂皮酸甲酯(10)、对羟基苯乙酮(11)、伞形花内酯(12)、3,4-二羟基苯乙酮(13)、胡萝卜苷(14)、1,5-二咖啡酰奎宁酸(15)、对羟基桂皮酸(16)、咖啡酸(17)及七叶内酯(18),其中化合物4~5,8,10,13,15及17,18为首次从该植物中分离得到。更多还原

【Abstract】 18 compounds were isolated and purified from the rhizomes of Ligularia vellerea. Their structures were determined on the basis of the physiochemical properties and spectroscopy analysis as furanoeremophilan-14β,6α-olide( 1), β-sitosterol( 2),tiglic acid( 3),palmitic acid( 4),nonadecanoic acid methyl ester( 5),eremophil-7( 11)-en-12,8α( 14β,6α)-diolide( 6),8β-methoxy-eremophil-7( 11)-en-12,8α( 14β,6α)-diolide( 7),1-O-palmitoylglycerol( 8), 8β-hydroxy-eremophil-7( 11)-en-12,8α( 14β,6α)-diolide( 9),p-hydroxycinnamic acid methyl ester( 10),phydroxyacetophenone( 11),umbelliferone( 12),3,4-dihydroxyacetophenone1( 13),daucosterol( 14),1,5-dicaffeoylquinic acid( 15),p-hydroxycinnamic acid( 16),caffeic acid( 17),aesculetin( 6,7-dihydroxycoumarin)( 18). Compounds 4-5,8,10,13,15 and 17,18 are firstly obtained from Ligularia vellerea.更多还原