【摘要】 目的探讨网膜素-1(Omentin-1)、高敏C反应蛋白(hs-CRP)水平与冠心病的相关性。方法 68例冠心病患者分为不稳定型心绞痛(UAP)组36例,稳定型心绞痛(SAP)组32例,30例冠状动脉造影结果正常者为对照组。采用酶联免疫吸附法(ELISA)测定血清Omentin-1水平,增强免疫透射比浊法测定血清hs-CRP水平。结果冠心病患者血清Omentin-1水平低于对照组,hs-CRP水平高于对照组(均P<0.05);SAP组血清hs-CRP低于UAP组(P<0.05),而Omentin-1水平差异无统计学意义。单支、双支、三支病变组患者血清Omentin-1水平均低于对照组,血清hs-CRP水平均高于对照组(均P<0.05),单支、双支与三支病变组间Omentin-1、hs-CRP水平差异无统计学意义。冠心病患者血清Omentin-1与hs-CRP的水平呈负相关(P<0.01)。结论 Omentin-1、hs-CRP与冠心病存在一定的相关性,但并不能反映冠状动脉狭窄程度及范围。更多还原

【Abstract】 Objective To evaluate the correlation of Omentin-1,the high sensitivity C-reactive protein(hsCRP) and coronary heart disease(CHD). Methods Sixty-eight patients with CHD were divided into the unstable angina pectoris(UAP) group(n =36),stable angina pectoris(SAP) group(n=32). And 30 normal subjects without CHD diagnosed by coronary arteriography(CAG) were served as the control group. The serum level of Omentin-1 was measured by enzyme linked immunosorbent assay(ELISA) and the serum level of hsCRP was measured by turbidmetric immunoassay. Results The serum level of Omentin-1 was significantly lower,but the serum level of hsCRP was significantly higher in CHD group than that of control group(P < 0.05). The serum level of hsCRP was significantly lower in SAP group than that of UAP group(P<0.05). There was no significant difference in serum level of Omentin-1 between groups(P > 0.05). The serum level of Omentin-1 was significantly lower in patients with single,double and three-vessel lesion group than that of control group,but the serum level of hsCRP was significantly higher in CHD group than that of control group(P < 0.05). There were no significant difference in serum levels of Omentin-1 and hs-CRP between single,double and three-vessel lesion groups(P > 0.05). The serum level of Omentin-1 was negatively correlated with serum level of hsCRP(P<0.01). Conclusion The serum level of Omentin-1 and hsCRP may correlate with CHD,but which may not reflect the severity of artery stenosis.更多还原