Association between Promoter Polymorphisms of Interleukin-4 Gene and Allergic Rhinitis Risk: a Meta-analysis

【摘要】 The relationship of interleukin-4(IL-4) C-33T and C-590T(C-589T) gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T and C-590T(C-589T)] and their association with allergic diseases and correlation between serum IL-4 levels and allergic rhinitis were retrieved. The Stata 12.0 statistical software was applied to analyze the correlation between IL-4 gene polymorphisms and allergic rhinitis. The meta-analysis result of TT/CC genotype of-590(-589) polymorphism showed a significant association with allergic diseases [OR=1.93, 95% CI(1.61–2.31), P=0.00]. Meta-analysis of the TT+TC versus CC genotype of IL-4 C-33/T polymorphism revealed significant associations with allergic diseases [OR=3.23, 95% CI(1.13–9.25), P=0.03]. Meanwhile, there was a significant correlation between serum IL-4 levels and allergic rhinitis [OR=2.52, 95% CI=(1.80–3.23), P=0.00]. IL-4 gene-590 TT genotype may increase the risk of allergic rhinitis and the T allele mutation of-33 might be correlated with allergic rhinitis.更多还原

【Abstract】 The relationship of interleukin-4(IL-4) C-33T and C-590T(C-589T) gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T and C-590T(C-589T)] and their association with allergic diseases and correlation between serum IL-4 levels and allergic rhinitis were retrieved. The Stata 12.0 statistical software was applied to analyze the correlation between IL-4 gene polymorphisms and allergic rhinitis. The meta-analysis result of TT/CC genotype of-590(-589) polymorphism showed a significant association with allergic diseases [OR=1.93, 95% CI(1.61–2.31), P=0.00]. Meta-analysis of the TT+TC versus CC genotype of IL-4 C-33/T polymorphism revealed significant associations with allergic diseases [OR=3.23, 95% CI(1.13–9.25), P=0.03]. Meanwhile, there was a significant correlation between serum IL-4 levels and allergic rhinitis [OR=2.52, 95% CI=(1.80–3.23), P=0.00]. IL-4 gene-590 TT genotype may increase the risk of allergic rhinitis and the T allele mutation of-33 might be correlated with allergic rhinitis.更多还原