【摘要】 赖氨酸特异性组蛋白去甲基化酶（LSD1）是一个黄素腺嘌呤二核苷酸（FAD）依赖性单胺氧化酶,它能够特异性脱去单甲基化和二甲基化H3K4和H3K9位点上的甲基基团,从而调节基因的转录活性。LSD1对哺乳动物的发育至关重要,并参与许多生物学过程,包括细胞类型的分化、基因活化和基因抑制。目前证实LSD1可促进细胞相变（缺乏LSD1导致部分细胞周期阻滞在G₂/M期）和细胞增殖,提示其过表达可促进肿瘤的发生。LSD1作为一种去甲基化酶,有可能成为一个新的抗肿瘤治疗靶点。现对LSD1的结构、作用方式以及其与肿瘤发生的关系等方面进行综述。更多还原

【Abstract】 Lysine specific demethylase 1（LSD1） is a kind of flavin adenine dinucleotid（FAD） dependent amine oxidase and can specifically demethylate H3K4me2/mel and H3K9me2/mel,thus it can regulate gene transcriptional activity.LSD1 is essential for mammalian development and is involved in many biological processes,including cell differentiation,gene activation,and gene repression.Nowadays,it is demonstrated that LSD1 might promote cell phase transition（deficiency in LSD1 leads to partial cell cycle arrest in G₂/M）and cell proliferation,suggesting that the over- expression of LSD1 might promote tumorigenesis.LSD1,as a demethylase,may be a new target for anti-cancer therapy.Hereby,we review on the structure,action mode of LSD1 and its relationship with oncogenesis.更多还原