【摘要】 恶性淋巴瘤的发病机制一直是肿瘤研究的一个重要课题,但至今尚不完全明确。最近有临床研究表明TLR4(Toll-like receptor 4,TLR4)在套细胞淋巴瘤组织中和多种淋巴瘤细胞系中均有较高表达,且与预后有一定相关性。本文对TLR4在恶性淋巴瘤发生发展中的作用做一综述,以阐明淋巴瘤发病机制并为其治疗提供新的依据。更多还原

【Abstract】 The pathogenesis of malignant lymphoma has been an important topic in tumor research,but it is still unclear.Recent clinical studies showed that the expression level of Toll- like receptor 4(TLR4) was significantly high in mantle cell lymphoma tissue and a variety of lymphoma cell lines.At the same time,the TLR4 expression level was correlated with prognosis.The Role of TLR4 in malignant lymphoma for occurrence and development is reviewed in this article,which may elucidate the pathogenesis and provide a new basis for the therapy of lymphoma.更多还原