【摘要】 星形细胞上调基因(Astrosyte elevated gene 1,AEG-1)具有促进癌症发生和发展的作用。AEG-1的过表达与血管生成、转移、及不同组织起源的癌细胞与各种化疗药物耐药有关。研究表明,AEG-1通过Ha-ras、myc、NF-κB及PI3K/Akt信号通路参与经典致癌途径。AEG-1通过激活AMP激酶来促进自噬作用。另有研究指出,AEG-1调节耐药性是通过多药耐药基因(Multidrug resistance,MDR1)mRNA表达增加多聚核糖体的负载量,从而促进MDR1蛋白翻译。近来证明AEG-1作为一种RNA结合蛋白潜在影响药物的敏感性和耐药基因的表达。AEG-1耐药性的多重功能显示,它作为抗肿瘤药物的靶点,为肿瘤靶向治疗提供新的途径是可行的。本文主要就AEG-1在化疗药物耐药方面的作用做一综述。更多还原

【Abstract】 It has been demonstrated that astrocyte elevated gene 1(AEG- 1) can promote tumor initiation and progression.Over expression of AEG- 1 is correlated with tumor angiogenesis,metastasis and chemotherapy resistance of tumor cells of different origins.The present article is a review on the mechanism of AEG- 1 mediated drug resistance.Studies have shown that AEG- 1 participates in carcinogenesis through Ha- ras,mye,NF- κB and PDK/Akt signalling pathways.AEG- 1 can also promote autophagy through activating AMP Kinase.Other researchers demonstrate that AEG- 1 promotes MDR1 protein translation by up- regulating MDR1 mRNA expression,and thus increases polyribosome.It is testified that AEG-1 can influence drug susceptibility and expression of MDR gene as a RNA binding protein.Multiple functions of AEG- 1 in drug resistance in multiple cancers demonstrate that AEG- 1 can be used as a novel target for antitumor drugs.更多还原