【摘要】 放疗在肺癌治疗中占有重要地位,在放疗中放射性肺损伤是治疗过程中的主要并发症,如何在临床治疗中早期预测放射性肺损伤的发生,对于疾病的治疗及预后具有重大意义。TGF-β1(Transforming growth factor-β1)可诱导炎性细胞包括淋巴细胞、中性粒细胞、单核细胞等促使纤维化的形成,采血检测发现放疗后发生放射性肺损伤的患者中,在放疗不同时期血浆TGF-β1表达水平发生变化,因此本文从细胞因子TGF-β1着手,综述了其单独、联合放射物理、其他细胞因子、基因等多方面探讨其在预测放射性肺损伤方面的价值。更多还原

【Abstract】 Radiotherapy plays an important role in the treatment of lung cancer.Radiation- induced lung injury is a major complication in the process of radiotherapy.It is of great significance for the treatment and prognosis of the diseases to predict the early stage of radiation- induced lung injury in the clinical treatment.TGF-Bl(transforming growthfactor- β1) can induce some inflammatory cells including lymphocytes,neutrophils,monocytes ect,contributing to the formation of fibrosis.Plasma TGF- β1 shows different levels followed different stages of radiation- induced lung injury.This article reviews the value of cytokine TGF- β1 in predicting the radiation- induced lung injury over various aspects such as singlely used,combined with radiation physics and other cytokines,and genomics.更多还原